Aston-Derks paper appears in Journal of Mathematical Biology

jmbThe paper A mathematical analysis of rebound in a target-mediated drug disposition model: II. With feedback, co-authored by Philip Aston, Gianne Derks, Balaji Agoram (Medimmune, Cambridge), and Piet van der Graaf (Leiden & Certara QSP, Canterbury), has been accepted for publication in the Journal of Mathematical Biology. The paper considers the possibility of free receptor (antigen/cytokine) levels rebounding to higher than the baseline level after the application of an antibody drug using a target-mediated drug disposition model which includes feedback in the production of the receptor.